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1B and S1A) in ACT suggested mitochondrial ribosome instability, which we confirmed using label-free quantitative proteomics (Fig

In some aspects disclosed herein (2,2-Difluoro-ethyl)-[3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-methyl-amine is pharmaceutical composition comprising a free base or a salt of a pharmaceutically acceptable acid other than hydrochloric, preferably without limitation nitric, sulfuric, methanesulfonic, ethylsulfonic, hydroxyethanesulfonic, sulfosalicylic, ethanedisulfonic, methylsulfuric, or trifluoroacetic

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

Nat Genet 2010